What is a pathogen? Toward a process view of host-parasite interactions

Pierre-Olivier Méthot, Samuel Alizon « What is a pathogen? Toward a process view of host-parasite interactions », Virulence, vol. 5, no 8 (2014) pp. 775-785

Until quite recently and since the late 19th century, medical microbiology has been based on the assumption that some micro-organisms are pathogens and others are not. This binary view is now strongly criticized and is even becoming untenable. We first provide a historical overview of the changing nature of host-parasite interactions, in which we argue that large-scale sequencing not only shows that identifying the roots of pathogenesis is much more complicated than previously thought, but also forces us to reconsider what a pathogen is. To address the challenge of defining a pathogen in post-genomic science, we present and discuss recent results that embrace the microbial genetic diversity (both within- and between-host) and underline the relevance of microbial ecology and evolution. By analyzing and extending earlier work on the concept of pathogen, we propose pathogenicity (or virulence) should be viewed as a dynamical feature of an interaction between a host and microbes.

Mis à jour le 3 octobre 2016 à 14 h 37 min.